The antimicrobial activity and biocompatibility of a controlled gentamicin-releasing single-layer sol-gel coating on hydroxyapatite-coated titanium.

Aims: The aim of this study was to develop a single-layer hybrid organic-inorganic sol-gel coating that is capable of a controlled antibiotic release for cementless hydroxyapatite (HA)-coated titanium orthopaedic prostheses.

Methods: Coatings containing gentamicin at a concentration of 1.25% weight/volume (wt/vol), similar to that found in commercially available antibiotic-loaded bone cement, were prepared and tested in the laboratory for: kinetics of antibiotic release; activity against planktonic and biofilm bacterial cultures; biocompatibility with cultured mammalian cells; and physical bonding to the material (n = 3 in all tests).

Corrosion protection mechanism of Ce/organic inhibitor for AA2024 in 3.5% NaCl.

Cerium is a rare earth element that has been widely proposed for the corrosion protection of aluminium alloys (AA). Both cerium salts, Ce and Ce, have been used in combination with other compounds to offer synergistic inhibition, however, the inhibitive corrosion mechanism when using Ce with organic compounds is still not clear. In this study, the synergistic inhibition effect of Ce and melamine (M) on the corrosion of aluminium alloy 2024 (AA2024) in 3.

Gemini surfactant as multifunctional corrosion and biocorrosion inhibitors for mild steel.

Biocorrosion is an important type of corrosion which leads to economic losses across oil and gas industries, due to increased monitoring, maintenance, and a reduction in platform availability. Ideally, a chemical compound engineered to mitigate against biocorrosion would possess both antimicrobial properties, as well as efficient corrosion inhibition. Gemini surfactants have shown efficacy in both of these properties, however there still remains a lack of electrochemical information regarding biocorrosion inhibition.

Analysis of linezolid and tigecycline as candidates for local prophylaxis via antibiotic-loaded bone cement.

Objectives: To assess the Gram-positive-specific antibiotic linezolid and the broad-spectrum antibiotic tigecycline for use in local antibiotic delivery via antibiotic-loaded bone cement.

Methods: Linezolid and tigecycline were added to Biomet bone cement at varying concentrations. Antibiotic elution over 1 week was quantified by HPLC-MS.

Current and emerging environmentally-friendly systems for fouling control in the marine environment.

Following the ban in 2003 on the use of tributyl-tin compounds in antifouling coatings, the search for an environmentally-friendly alternative has accelerated. Biocidal TBT alternatives, such as diuron and Irgarol 1051®, have proved to be environmentally damaging to marine organisms. The issue regarding the use of biocides is that concerning the half-life of the compounds which allow a perpetuation of the toxic effects into the marine food chain, and initiate changes in the early stages of the organisms' life-cycle.