Publications by authors named "R Akazawa"
The prognosis of patients with osteosarcoma who experience recurrence or progression (R/P) is extremely poor, and more effective and less toxic therapies are needed. In the current study, the clinical data of osteosarcoma patients who experienced R/P were retrospectively analyzed to verify the reliability of O-6-methylguanine-DNA methyltransferase (MGMT) protein expression or MGMT promoter methylation for predicting the response to off-label temozolomide (TMZ)-containing chemotherapy. Of the 30 evaluable patients, 9 (30%) showed no/low MGMT protein expression, whereas all 16 evaluable patients had unmethylated MGMT promoter irrespective of MGMT protein expression levels.
View Article and Find Full Text PDFImpact of Nitroxyl Radicals on Photovoltaic Conversion Properties of Dye-Sensitized Solar Cells.
Materials (Basel)
December 2023
Nitroxyl radicals, characterized by unique redox properties, have been investigated for their potential influence on the photovoltaic conversion properties of dye-sensitized solar cells (DSSCs). In this study, we investigated the influence of nitroxyl radicals as donor sites in DSSCs. We observed that the redox activity of nitroxyl radicals significantly enhanced the photovoltaic conversion efficiency of DSSCs; this finding can offer new insights into the application of these radicals in solar energy conversion.
View Article and Find Full Text PDFArticle Synopsis
- - KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) is a challenging type of childhood leukemia, and researchers conducted extensive genetic studies on 84 infants with this condition to understand its complexity.
- - The analysis revealed five distinct clusters of the disease, each characterized by different genetic factors and stages of blood cell development, which include various types of IRX and HOXA gene involvement.
- - A key finding is that specific mutations in the RAS pathway can predict patient outcomes, with one subgroup showing a high mutation rate and severe prognosis, emphasizing the need for personalized treatment strategies based on genetic insights.
Article Synopsis
- Patients with osteosarcoma who experience relapse or progression have a poor prognosis, but recent data shows improved outcomes in a study analyzing 30 such patients under 40 years old.
- The 5-year overall survival rates after relapse for these patients were 50.3% after first relapse, slightly above rates from previous studies, suggesting surgical interventions play a key role in enhancing survival.
- Factors like histologic subtype and successful local surgery were linked to better progression-free survival, and certain chemotherapy combinations yielded partial responses in some patients, indicating potential new treatments could aid in improving outcomes.