Triadenosides A-F, benzophenone rhamnosides from Triadenum japonicum and their anti-ferroptosis activity.

Previously undescribed benzophenone rhamnosides, triadenosides A-F (1-6), were isolated from the aerial parts of Triadenum japonicum (Blume) Makino (Hypericaceae), where known compounds including benzophenone rhamnosides (7 and 8), benzophenone C-glucoside (9), flavonols and their glycosides (10-17), and biflavone (18) were also isolated and identified. Detailed spectroscopic analysis revealed that triadenoside A (1) was 2,3',5'-trihydroxy-4,6-dimethoxybenzophenone 2-O-α-L-rhamnopyranoside, while the absolute configuration of the rhamnosyl moiety was confirmed by HPLC analysis. Triadenosides B-E (2-5) were assigned as acetyl derivatives of 1 in their rhamnosyl moieties.

Species-specific differences in acetaminophen hepatotoxicity depend on HSP70 expression level.

Acetaminophen (N-Acetyl-p-aminophenol: APAP) is one of the most commonly used analgesic/antipyretic drugs with proven safety at therapeutic doses, however, over-dosage causes dose-dependent liver damage, leading to acute liver failure in severe cases. The level of APAP-induced liver injury has been known to vary among animal species, and APAP concentrations that induce cell death have been investigated using primary cultured cells. We constructed in vitro model of APAP-induced hepatotoxicity using mouse, rat, and human hepatoma cell lines to investigate species differences in the APAP-induced cytotoxicity by monitoring cell death as a marker.

Instrument-assisted soft tissue mobilization in healthy adults acutely changes the tissue stiffness.

This study clarified whether instrument-assisted soft tissue mobilization (IASTM) on the plantar surface changes abductor hallucis and plantar fascia stiffness at rest and medial longitudinal arch height under low- and high-loading conditions. IASTM was performed to one foot of the twenty-eight young men (IASTM condition), and the other foot of them was assigned to the control condition. Using ultrasonography, the resting shear wave propagation velocity of the abductor hallucis and plantar fascia and navicular height in a seated posture were determined.

Cryotherapy with carbon dioxide hydrate enhances immediate recovery of muscle function from neuromuscular fatigue.

This study investigated the effect of cryotherapy with carbon dioxide hydrate (CDH) on fatigue recovery of neuromuscular function and muscle blood circulation. Fourteen young males randomly received three types of 20-min recovery interventions (cryotherapy with CDH [CDH-condition] or normal ice [ICE-condition], or quiet sitting at room temperature [CON-condition]) 5 min following a fatiguing task (50 maximal effort isotonic contractions) on three separate days. The isotonic peak power of the knee extensors at 35 min after the fatiguing task in the CDH-condition (95% of baseline) was greater than that in the other conditions (82-89% of baseline;  ≤ 0.