Publications by authors named "R Ain"
Cellular prion protein (PRNP) has been implicated in various physiological processes in different cell types, for decades. Little has been known how PRNP functions in multiple, yet related processes within a particular system. In our current study, with the aid of high-throughput RNA-sequencing technique, we have presented an overall transcriptome profile of rat vascular smooth muscle cells (VSMCs) with Prnp knockdown.
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- There is limited data on cancers associated with primary immunodeficiencies (PIDs) in children in low-middle-income countries, so this study examined their incidence and outcomes in Pakistan.
- Out of 5,748 children with cancers, only eight had PID-associated malignancies, resulting in an incidence rate of 1.4 per 1,000, with a median diagnosis age of 6.5 years and a 7:1 male-to-female ratio.
- The prognosis for these patients was poor, with a median survival of only 3.5 months, primarily due to infection-related deaths; the study suggests improved awareness and screening for PIDs might enhance treatment outcomes.
Vascular smooth muscle cell (VSMC) plasticity is fundamental in uterine spiral artery remodeling during placentation in Eutherian mammals. Our previous work showed that the invasion of trophoblast cells into uterine myometrium coincides with a phenotypic change of VSMCs. Here, we elucidate the mechanism by which trophoblast cells confer VSMC plasticity.
View Article and Find Full Text PDFHypoxia-inducible factors (HIFs) are essential to the homeostasis of hypoxic tissues. Although HIF-2α, is expressed in nucleus pulposus (NP) cells, consequences of elevated HIF-2 activity on disc health remains unknown. We expressed HIF-2α with proline to alanine substitutions (P405A; P531A) in the Oxygen-dependent degradation domain (HIF-2αdPA) in the NP tissue using an inducible, nucleus pulposus-specific K19 allele to study HIF-2α function in the adult intervertebral disc.
View Article and Find Full Text PDFHypoxia-inducible factors (HIFs) are essential to the homeostasis of hypoxic tissues. Although HIF-2α, is expressed in nucleus pulposus (NP) cells, consequences of elevated HIF-2 activity on disc health remains unknown. We expressed HIF-2α with proline to alanine substitutions (P405A;P531A) in the Oxygen-dependent degradation domain (HIF-2αdPA) in the NP tissue using an inducible, nucleus pulposus-specific K19 allele to study HIF-2α function in the adult intervertebral disc.
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