Publications by authors named "R Afridi"

Microglia-mediated neuroinflammation has been implicated in the neuropathology of traumatic brain injuries (TBI). Recently, the expression of interleukin-2-inducible T-cell kinase (ITK) has been detected in brain microglia, regulating their inflammatory activities. However, the role of microglial ITK in TBI has not been investigated.

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Background Coronary artery disease (CAD) significantly contributes to morbidity and mortality globally, particularly in individuals with diabetes mellitus, who are at a heightened risk for cardiovascular complications. The complexity of coronary lesions and diffuse atherosclerosis in diabetic patients presents challenges in their treatment and prognosis. Coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) are primary revascularization strategies for managing multi-vessel CAD in diabetic patients.

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Can a robotic gripper only operate when attached to a robotic arm? The application space of the traditional gripper is limited by the robotic arm. Giving robot grippers the ability to move will expand their range of applications. Inspired by rich behavioral repertoire observed in octopus, we implement an integrated multifunctional soft robotic gripper with 6 independently controlled Arms.

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Article Synopsis
  • - Studies indicate that astrocytes in the medullary dorsal horn (MDH) are crucial in developing pathological pain, yet their structural changes, specifically in peripheral astrocytic processes (PAP), during neuropathic states are not well understood.
  • - Research using a rat model post-chronic constriction injury revealed significant increases in the number, area, density, and coverage of ezrin-positive PAPs around presynaptic axon terminals and postsynaptic dendrites compared to control rats.
  • - The administration of the mGluR5 antagonist MPEP reversed these structural changes, suggesting that mGluR5 may mediate the reorganization of PAPs and enhance astrocyte-neuron interactions in neuropath
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