Publications by authors named "R Adorisio"
Kirsten rat sarcoma viral oncogene homolog (KRAS) somatic mutations occur in 30% to 40% of patients with colorectal cancer (CRC). These were thought to equally affect prognosis and resistance to anti-epidermal growth factor receptor agents; however, recent data show the activity of KRAS-G12C and pan-RAS inhibitors. The effects of uncommon KRAS (uKRAS) variants are largely unexplored.
View Article and Find Full Text PDFHypothesis: The aim of the study was to evaluate the correlation between NTproBNP and left ventricular mass (LVM) in children affected by hypertrophic cardiomyopathy (HCM), both asymptomatic, symptomatic, and with implantable cardioverter-defibrillator (ICD).
Methods: A total of 225 pediatric patients were evaluated and 45 were enrolled in the study because met inclusion criteria (age < 18 years; diagnosis of hypertrophic cardiomyopathy; NTproBNP > 600 pg/ml).
Results: The analysis showed a significant correlation between NTproBNP level and LVM (p = 0.
Article Synopsis
- Duchenne Muscular Dystrophy (DMD) is a serious, progressive disorder that leads to muscle wasting and other complications, requiring a combination of therapies and new approaches to patient care.
- Experts in Italy discussed the challenges of transitioning care for DMD patients from pediatric to adult services, emphasizing the importance of continuous treatment and tracking relevant health outcomes after patients lose their ability to walk.
- Following loss of ambulation, care shifts focus toward cardiac and respiratory health, nutrition, and the maintenance of upper limb function, highlighting the need for shared protocols and better data collection for optimized management.
Article Synopsis
- Left ventricular hypertrabeculation (LVHT) is a heart condition that can lead to various symptoms, including serious issues like heart failure and arrhythmias, making it difficult to identify which cases are benign versus pathological.
- A study analyzed 140 pediatric patients with LVHT over ten years, and found that 23.6% of them experienced arrhythmias, with various types identified, including supraventricular and ventricular arrhythmias.
- Results indicated a significant relationship between specific genetic variants (class 4 or 5) and the occurrence of arrhythmias, while the patients generally had good outcomes, with no reported sudden cardiac deaths.
Article Synopsis
- Primary benign cardiac tumors in children are rare but can lead to serious complications like malignant ventricular arrhythmias and cardiac death.
- A study conducted over 38 years included 97 children with various types of tumors, revealing that those with tumors larger than 2.3 cm or diagnosed with fibromas had worse health outcomes.
- The research highlighted that 24.5% of the patients experienced clinically significant arrhythmias, suggesting that tumor type and size are important indicators of potential risks.