Publications by authors named "R Adapa"
Article Synopsis
- Neuroscientists are using network science to study interactions between brain regions, focusing on how to reconstruct these networks from resting-state functional MRI data.
- The study evaluates 768 different data-processing pipelines, considering factors like brain parcellation and sensitivity to movement, to identify which are best for analyzing brain function without producing misleading results.
- Results show significant variability in pipeline effectiveness, with many failing to meet key criteria, but a select group of optimal pipelines consistently perform well across various datasets, providing guidance for future research in functional connectomics.
To understand how pharmacological interventions can exert their powerful effects on brain function, we need to understand how they engage the brain's rich neurotransmitter landscape. Here, we bridge microscale molecular chemoarchitecture and pharmacologically induced macroscale functional reorganization, by relating the regional distribution of 19 neurotransmitter receptors and transporters obtained from positron emission tomography, and the regional changes in functional magnetic resonance imaging connectivity induced by 10 different mind-altering drugs: propofol, sevoflurane, ketamine, lysergic acid diethylamide (LSD), psilocybin, N,N-Dimethyltryptamine (DMT), ayahuasca, 3,4-methylenedioxymethamphetamine (MDMA), modafinil, and methylphenidate. Our results reveal a many-to-many mapping between psychoactive drugs' effects on brain function and multiple neurotransmitter systems.
View Article and Find Full Text PDFA central question in neuroscience is how consciousness arises from the dynamic interplay of brain structure and function. Here we decompose functional MRI signals from pathological and pharmacologically-induced perturbations of consciousness into distributed patterns of structure-function dependence across scales: the harmonic modes of the human structural connectome. We show that structure-function coupling is a generalisable indicator of consciousness that is under bi-directional neuromodulatory control.
View Article and Find Full Text PDFTypical consciousness can be defined as an individual-specific stream of experiences. Modern consciousness research on dynamic functional connectivity uses clustering techniques to create common bases on which to compare different individuals. We propose an alternative approach by combining modern theories of consciousness and insights arising from phenomenology and dynamical systems theory.
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