Publications by authors named "R Abounader"
Background: Glioblastoma (GBM) is the most common primary malignant brain tumor. The aim of this study was to elucidate the role of microenvironment and intrinsic T-type calcium channels (Cav3) in regulating tumor growth and progression.
Methods: We grafted syngeneic GBM cells into Cav3.
Article Synopsis
- TUCRs are a class of non-coding RNAs that are highly conserved across species and were analyzed for the first time in glioblastoma and low-grade gliomas.
- The study identified important genomic information about 481 TUCRs, focusing on their expression and potential roles in glioma biology.
- Uc.110, the most upregulated TUCR, was discovered to promote tumor growth by activating the WNT pathway, suggesting it functions as a new oncogene in brain tumors.
Transcribed Ultra-Conserved Regions (TUCRs) represent a severely understudied class of putative non-coding RNAs (ncRNAs) that are 100% conserved across multiple species. We performed the first-ever analysis of TUCRs in glioblastoma (GBM) and low-grade gliomas (LGG). We leveraged large human datasets to identify the genomic locations, chromatin accessibility, transcription, differential expression, correlation with survival, and predicted functions of all 481 TUCRs, and identified TUCRs that are relevant to glioma biology.
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