In vitro susceptibility to quinolones and other antimicrobial agents of Staphylococcus species isolated from immunocompromised patients.

A total of 237 Staphylococcus strains were isolated from different kinds of body tissues and fluids from immunocompromised patients admitted to the Hematology Department of Pescara Hospital (Italy). These strains, collected from November 1987 to September 1988, were studied for their susceptibility to methicillin and other drugs commonly used in therapy, and the minimum inhibitory and minimum bactericidal concentrations of five quinolones were determined. The killing curve of ciprofloxacin compared with nalidixic acid was determined.

[The production of enzymes inactivating various antibiotics obtained from Gram-negative bacteria recently isolated in the province of Chieti].

The Authors have studied the ability of producing enzymes blocking various antibiotics by 274 Gram-negative germs isolated in the years 1978-80 in the Province of Chieti (Italy). The results have showed that a high percentage of examined strains presents a polyresistance towards penicillins, cephalosporins, chloramphenicol and amino-glucosides producing in the same time beta-lactamase, acetyl-transferases and phospho-transferases.