Publications by authors named "R A de Paus"
Epidermal melanocytes form synaptic-like contacts with cutaneous nerve fibers, but the functional outcome of these connections remains elusive. In this pilot study we used our fully humanized re-innervated skin organ culture model to investigate melanocyte-nerve fiber interactions in UV-B-induced melanogenesis. UV-B-irradiation significantly enhanced melanin content and tyrosinase activity in re-innervated skin compared to non-innervated controls, indicating that neuronal presence is essential for exacerbating pigmentation upon UV-B irradiation in long-term culture.
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- VEGF-A is linked to the development of psoriasis, and while it's commonly used to treat cancer and eye diseases, its role in psoriasis treatment is not well understood.
- The study aimed to explore how inhibiting VEGF-A affects gene expression and pathways in both healthy and psoriatic skin samples.
- Results showed that VEGF-A inhibition led to changes in lipid metabolism and cell stress responses, indicating potential new avenues for psoriasis treatment, but further research is necessary to confirm these findings.