[Markers of apoptotic dysfunction in schizophrenia].

According to modern concepts, alterations of the apoptosis processes and its genetic regulation are involved in etiopathogenesis of schizophrenia. This is observed on the levels of both the brain and peripheral blood. However, studies in this aspect are on initial stage of development, and molecular and cellular mechanisms of abnormalities of apoptosis in schizophrenia are not clear.

[The effect of calcium precipitate of double-stranded RNA on erythropoiesis in rats with acute anemia].

On the model of experimental acute anaemia of rats, induced by injection of phenilhydrazine, the influence of calcium precipitate of double-stranded RNA (Ca-ds-RNA), introduced during the crise of anaemia, on the process of erythron restoration, was studied. In the presence of Ca-ds-RNA the number of pro- and erythroblasts in fission increases by 1.5 times, compared with "pure" anaemia situation, and accordingly there is a marked decrease in the share of microcytes, which play an important role in the restoration of cell number, and in the erythron recovery after the crise of anaemia.

[Regulation of Ca(2+)-dsRNA for proliferation and terminal differentiation processes of human fibroblasts and HeLa cells].

Ca2+ complexes of dsRNA, poly(dA) and poly(dT) of yeast low molecular weight RNA produce a pronounced mitogenic effect on human fibroblasts at early stages of fibroblast proliferation in culture. At later stages of cell cultivation Ca(2+)-dsRNA stimulates terminal differentiation by inducing the synthesis of proteins characteristic of the postmitotic population of human fibroblasts undergoing terminal differentiation. Ca(2+)-dsRNA produces a stimulating effect on c-fos and c-jun gene transcription in fibroblasts and HeLa-S-3.

[The effect of high molecular weight interferon inducers (dsRNA) on virus adsorption].

Interrelationship between phosphorylation of plasmatic membrane proteins in brain cells and the rate of mice encephalomyocarditis virus adsorption was studied. Phosphorylation of proteins induced by dsRNA (laryphane) was most distinctly manifested in membrane fraction and cytosol of rat brain neuronal cells. Similarity of molecular mass spectra in dsRNA- and cAMP-dependent phosphorylation enabled to suggest that dsRNA activated protein kinase.