Publications by authors named "R A Wanner"
Article Synopsis
- Endometrial cancer (EC) is the most common gynecological cancer in the U.S., with obesity contributing to 57% of cases, emphasizing the need to study its molecular mechanisms in relation to obesity.
- The research found that obese EC patients had higher levels of extracellular vesicles (EVs) carrying oncogenic proteins, which are linked to increased cancer growth, inflammation, and changes in protein expression in both adipose and uterine tissues.
- Treatments with small molecule inhibitors like HO-3867 and Metformin were effective in reducing EV secretion, slowing cancer cell proliferation, and inhibiting the early stages of cancer development in high-fat diet-induced models.
Hip arthroplasty is a common elective surgery worldwide, with rising numbers due to demographic changes and an emphasis on maintaining physical activity in the elderly. The development of new implant designs, especially shorter uncemented stems, has contributed to the advancement of minimally invasive implantation techniques. However, the long-term in vivo behaviour of these implants, particularly regarding subsidence, stability, and stress shielding, remains to be fully understood.
View Article and Find Full Text PDFVascular smooth muscle cells (VSMCs) envelop vertebrate brain arteries and play a crucial role in regulating cerebral blood flow and neurovascular coupling. The dedifferentiation of VSMCs is implicated in cerebrovascular disease and neurodegeneration. Despite its importance, the process of VSMC differentiation on brain arteries during development remains inadequately characterized.
View Article and Find Full Text PDFVascular smooth muscle cells (VSMCs) envelop vertebrate brain arteries, playing a crucial role in regulating cerebral blood flow and neurovascular coupling. The dedifferentiation of VSMCs is implicated in cerebrovascular diseases and neurodegeneration. Despite its importance, the process of VSMC differentiation on brain arteries during development remains inadequately characterized.
View Article and Find Full Text PDFLandscape evolution is driven by tectonics, climate and surface denudation. In New Zealand, tectonics and steep climatic gradients cause a dynamic landscape with intense chemical weathering, rapid soil formation, and high soil losses. In this study, soil, and elemental redistribution along two adjacent hillslopes in East Otago, New Zealand, having different landscape settings (ridge versus valley) are compared to identify soil weathering and erosion dynamics.
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