Impact of the Healthy Lifestyle Community Program (HLCP-3) on Trimethylamine N-Oxide (TMAO) and Risk Profile Parameters Related to Lifestyle Diseases During the Six Months Following an Intervention Study.

Rationale: The dietary components choline, betaine, and L-carnitine are converted by intestinal microbiota into the molecule trimethylamine (TMA). In the human liver, hepatic flavin-containing monooxygenase 3 oxidizes TMA to trimethylamine-N-oxide (TMAO). TMAO is considered a candidate marker for the risk of cardiovascular disease.

Long term substantial impacts of historic Chlor-Alkali production as a newly recognized source of polyhalogenated carbazoles in aquatic environments.

Bottom sediments of the North American Great Lakes are characterized by a high loading (over 3,000 tonnes) of polyhalogenated carbazoles (PHCZs). The origin of this environmental contaminant loading is unclear. Here, we first examined PHCZs levels and profiles in sediment, lotus, and fish from the Ya-Er Lake (China) that has been under the influence of an obsolete chlor-alkali facility for forty years and discovered substantial PHCZs contamination.

Selection of volatile markers for rubbery rot in apple fruit caused by Phacidiopycnis washingtonensis.

Although a major share of postharvest losses of apples is due to fungal fruit rots, their timely detection is difficult in commercial bulk-storage rooms. Therefore, a method was developed to identify the volatile markers of fruit naturally infected by Phacidiopycnis washingtonensis, a common storage-rot fungus of Northern Europe, and North and South America. Potato dextrose agar, apple juice agar, and fruit of the apple cultivar 'Nicoter' were inoculated with P.

Investigating polychlorinated alkanes in technical chlorinated paraffin mixtures and polymer products available in Vietnam.

Chlorinated paraffins (CPs) are chemical additives mostly composed of polychlorinated alkanes (PCAs) which may impact on the environment and human health; however, little is known about their presence in Southeast Asia. To fill this knowledge gap, we assessed 74 PCA homolog groups commonly referred to as short-chain (SCCPs: PCAs-C), medium-chain (MCCPs: PCAs-C), and long-chain CPs (LCCPs: PCAs-C) in technical CP mixtures (n = 4) and polymer samples (n = 49), including recycled plastics, collected in Vietnam in 2023. The contents of measured PCA homolog groups in technical CP mixtures were 86,000-930,000 mg/kg for PCAs-C; 85,000-990,000 mg/kg for PCAs-C; and 23,000-180,000 mg/kg for PCAs-C.

Circulating tumor cell plasticity determines breast cancer therapy resistance via neuregulin 1-HER3 signaling.

Circulating tumor cells (CTCs) drive metastasis, the leading cause of death in individuals with breast cancer. Due to their low abundance in the circulation, robust CTC expansion protocols are urgently needed to effectively study disease progression and therapy responses. Here we present the establishment of long-term CTC-derived organoids from female individuals with metastatic breast cancer.