Publications by authors named "R A Simonov"
Article Synopsis
- - Elys/Mel-28 is a nucleoporin (Nup) that connects decondensing chromatin with nuclear pore complexes (NPCs) after mitosis, but its role during interphase is unclear.
- - Research using DamID-seq in Drosophila embryos identified different Elys binding sites within active or inactive chromatin, revealing its interaction with nucleoplasmic and NPC-linked forms.
- - Knocking down Elys in S2 cells causes chromatin to move away from the nuclear envelope, leading to gene derepression, while also compacting active chromatin regions, suggesting Elys helps anchor peripheral chromatin to the nuclear envelope.
The diagnosis of intrathoracic non-tuberculous mycobacteriosis (NTM) is challenging. We report a case of a pediatric pulmonary NTM with endobronchial lesion and lymphadenitis in a child with HIV infection diagnosed by bronchoscopic biopsy, EBUS-TBNA and probe-based confocal laser endomicroscopy (pCLE). The pCLE showed a large number of highly fluorescent cells and zones of density and disorganized elastin fibers at alveolar areas.
View Article and Find Full Text PDFSjögren's syndrome is a systemic autoimmune disease characterized by lymphocytic infiltration of various organs with a wide frequency of pulmonary involvement. Diffuse cystic lung disease in Sjögren's syndrome is a rare condition and requires differential diagnosis with other cystic pathologies such as lymphangioleyomiomatosis or Langerhans cell histiocytosis. Probe-based confocal laser endomicroscopy (pCLE) is a method of in vivo investigation of airways and lung tissue at a microscopic level during bronchoscopy.
View Article and Find Full Text PDFRecently, the mRNA platform has become the method of choice in vaccine development to find new ways to fight infectious diseases. However, this approach has shortcomings, namely that mRNA vaccines require special storage conditions, which makes them less accessible. This instability is due to the fact that the five-prime and three-prime ends of the mRNA are a substrate for the ubiquitous exoribonucleases.
View Article and Find Full Text PDFArticle Synopsis
- Almost everyone gets infected with herpes viruses, like HSV-1, which can stay in a dormant state resistant to current antiviral treatments.
- Reactivation of these viruses can occur under certain conditions, and drug-resistant strains are becoming more common, highlighting the need for new treatment methods.
- The study explores CRISPR/Cas systems as a potential therapy, demonstrating that engineered plasmids can effectively suppress HSV-1 infection in cell cultures for extended periods.