Nurses who co-create care with clients experience lower levels of burnout through the perception of fewer emotional demands: an observational study.

Background: Clients are especially satisfied about treatment of nurses providing person-centered care. Such care benefits from the co-creation of care, in which nurses and clients together shape the care process by investing in effective communication and supportive nurse-client relationships. Co-creation of care can especially benefit longitudinal collaboration between clients and their nurses in long-term care settings.

A distributed integral control mechanism for regulation of cholesterol concentration in the human retina.

Tight homeostatic control of cholesterol concentration within the complex tissue microenvironment of the retina is the hallmark of a healthy eye. By contrast, dysregulation of biochemical mechanisms governing retinal cholesterol homeostasis likely contributes to the aetiology and progression of age-related macular degeneration (AMD). While the signalling mechanisms maintaining cellular cholesterol homeostasis are well-studied, a systems-level description of molecular interactions regulating cholesterol balance within the human retina remains elusive.

Study demands and resources affect academic well-being and life satisfaction of undergraduate medical students in the Netherlands.

Introduction: Medical students report poor academic well-being in a context of high study demands. Study Demands-Resources theories have outlined mediating processes involving high study demands and low resources to mitigate academic well-being, which is subsequently associated with diminished overall well-being (i.e.

Robust homeostasis of cellular cholesterol is a consequence of endogenous antithetic integral control.

Although cholesterol is essential for cellular viability and proliferation, it is highly toxic in excess. The concentration of cellular cholesterol must therefore be maintained within tight tolerances, and is thought to be subject to a stringent form of homeostasis known as Robust Perfect Adaptation (RPA). While much is known about the cellular signalling interactions involved in cholesterol regulation, the specific chemical reaction network structures that might be responsible for the robust homeostatic regulation of cellular cholesterol have been entirely unclear until now.