Publications by authors named "R A Sayegh"
Background: Tildrakizumab is an interleukin-23 inhibitor approved in Canada in 2021 for the treatment of adults with moderate-to-severe plaque psoriasis.
Objectives: To evaluate real-world effectiveness of tildrakizumab for the treatment of moderate-to-severe plaque psoriasis in Canada.
Methods: A multicenter, retrospective study was conducted in Canada in adults with moderate-to-severe plaque psoriasis for ≥1 year treated with tildrakizumab for ≥12 weeks.
Quantifying the Corneal Nerve Whorl Pattern.
Transl Vis Sci Technol
December 2024
Purpose: The corneal nerves within the sub-basal nerve plexus (SBNP) display a distinctive whorl-like pattern, a highly dynamic structure that could be a marker of diseases. Previous studies have reported a decrease in whorl nerve density in patients with diabetes, indicating an avenue for noninvasive monitoring of diabetic neuropathy. However, conflicting results have since been reported, highlighting the need for improved quantitative analysis of the corneal whorl.
View Article and Find Full Text PDFArticle Synopsis
- - This study focused on community-acquired pneumonia (CAP) in children, aiming to identify mucosal biomarkers that can aid in determining the severity and cause of the illness.
- - Researchers analyzed cytokine levels in nasopharyngeal samples from 182 children with CAP and 26 healthy controls, finding that those with atypical bacteria and influenza virus had significantly elevated cytokine concentrations compared to those with typical bacteria.
- - The findings suggest that differences in inflammatory and antiviral cytokine levels correlate with disease severity in CAP, indicating that mucosal biomarkers might be helpful for better assessing and classifying the condition in pediatric patients.
Immunoregulation of Liver Fibrosis: New Opportunities for Antifibrotic Therapy.
Annu Rev Pharmacol Toxicol
September 2024
Liver fibrosis develops in response to chronic liver injury and is characterized by a sustained inflammatory response that leads to excessive collagen deposition by myofibroblasts. The fibrogenic response is governed by the release of inflammatory mediators from innate, adaptive, and innate-like lymphoid cells and from nonprofessional immune cells (i.e.
View Article and Find Full Text PDFErgonomic considerations for the modern radiology practice: An update.
Curr Probl Diagn Radiol
September 2024
The average post-pandemic modern radiology practice is experiencing an ever-increasing workload volume with overall relatively similar staffing levels, regardless of practice setting. This has resulted in an increased workload demand for the average diagnostic radiologist, which in many cases translates to longer working hours. It is now more important than ever to be cognizant of various work-related injuries, including repetitive-stress injuries and vision-related ailments as examples, in relation to the working conditions of the radiologist.
View Article and Find Full Text PDF