Publications by authors named "R A Saladino"
UVB radiation induces DNA damage generating several thymine photo-adducts (TDPs), which can lead to mutations and cellular transformation. The DNA repair pathways preserve genomic stability by recognizing and removing photodamage. These DNA repair side products may affect cellular processes.
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- Formamide, when reacting with a catalyst and energy, produces a variety of important compounds like amino acids, sugars, and nucleic bases, which are the building blocks of life.
- Different catalysts yield unique product sets, but there's significant overlap in the types of compounds formed, indicating a robust chemical process.
- The findings suggest that the early conditions on Earth for creating life-like molecules were straightforward and did not require unusual environments, supporting the idea of a predictable prebiotic chemistry.
Molecular hybridization is a widely used strategy in drug discovery and development processes that consists of the combination of two bioactive compounds toward a novel entity. In the current study, two libraries of hybrid derivatives coming from the linkage of sesquiterpene counterparts dihydroartemisinin and artesunic acid, with a series of monoterpenes, were synthesized and evaluated by cell viability assay on primary and metastatic melanoma cell lines. Almost all the obtained compounds showed micromolar antimelanoma activity and selectivity toward the metastatic form of this cancer.
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- Pediatric craniofacial fractures when compared to adults exhibit different injury patterns and can affect future growth, highlighting the need for tailored management strategies.* -
- This study analyzed over 3,000 patients under 18 at a pediatric trauma center from 2006 to 2021, revealing demographics, causes of injury, types of fractures, and treatment requirements based on age.* -
- Key findings included that older children primarily sustained fractures from sports while younger ones had more orbital and skull fractures, along with a notable prevalence of associated injuries like soft tissue and neurologic damage.*
The use of privileged scaffolds as a starting point for the construction of libraries of bioactive compounds is a widely used strategy in drug discovery and development. Scaffold decoration, morphing and hopping are additional techniques that enable the modification of the chosen privileged framework and better explore the chemical space around it. In this study, two series of highly functionalized pyrimidine and pyridine derivatives were synthesized using a scaffold morphing approach consisting of triazine compounds obtained previously as antiviral agents.
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