Publications by authors named "R A Rezende"
Article Synopsis
- - The study examined how tryptophan (Trp) and low-intensity exercise affect mechanical hypersensitivity in a fibromyalgia-like model using acid saline injections in female rats.
- - Results showed that both Trp supplementation and exercise reduced hypersensitivity, with the combination of both treatments having the most significant effect, while exercise alone did not change levels of key brain metabolites.
- - The findings suggest that Trp supplementation enhances its metabolism and might help manage hypersensitivity in fibromyalgia, but the results are preliminary, so caution is advised in generalizing these outcomes.
Predictors of Hospitalization in Breakthrough COVID-19 among Fully Vaccinated Individuals with Immune-Mediated Rheumatic Diseases: Data from SAFER-Study.
Vaccines (Basel)
September 2024
Breakthrough COVID-19 (occurring in fully vaccinated people) has been described. Data on its characteristics among immune-mediated rheumatic disease (IMRD) patients are scarce. This study describes breakthrough COVID-19 occurring in IMRD patients participating in the SAFER-study, a Brazilian multicentric cohort evaluating the safety, effectiveness, and immunogenicity of SARS-CoV-2 vaccines in patients with autoimmune diseases.
View Article and Find Full Text PDFMitoviruses are cryptic capsidless viruses belonging to the family Mitoviridae that replicate and are maintained in the mitochondria of fungi. Complete mitovirus-like sequences were recently assembled from plant transcriptome data and plant leaf tissue samples. Passion fruit (Passiflora spp.
View Article and Find Full Text PDFSafety of CoronaVac and ChAdOx1 vaccines against SARS-CoV-2 in patients with rheumatoid arthritis: data from the Brazilian multicentric study safer.
Adv Rheumatol
August 2024
Background: Patients with immune-mediated rheumatic diseases (IMRDs) have been prioritized for COVID-19 vaccination to mitigate the infection severity risks. Patients with rheumatoid arthritis (RA) are at a high risk of severe COVID-19 outcomes, especially those under immunosuppression or with associated comorbidities. However, few studies have assessed the safety of the COVID-19 vaccine in patients with RA.
View Article and Find Full Text PDFThis study aims to evaluate the impact of liver fibrosis stages of chronic infection with hepatitis C virus (HCV) on the in vivo activity of organic cation transporters (hepatic OCT1 and renal OCT2) using metformin (MET) as a probe drug. Participants allocated in Group 1 ( = 15, mild to moderate liver fibrosis) or 2 ( = 13, advanced liver fibrosis and cirrhosis) received a single MET 50 mg oral dose before direct-acting antiviral (DAA) drug treatment (Phase 1) and 30 days after achieving sustained virologic response (Phase 2). OCT1/2 activity (MET AUC) was found to be reduced by 25% when comparing the two groups in Phase 2 (ratio 0.
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