Publications by authors named "R A Quaife"
Article Synopsis
- This study distinguishes between nondilated left ventricular cardiomyopathy (NDLVC) and dilated cardiomyopathy (DCM) by using cardiac magnetic resonance (CMR) and genetic testing on 462 patients across four centers.
- Findings showed that NDLVC patients had better heart function and a higher prevalence of specific genetic variants compared to those with DCM, highlighting significant differences in their conditions.
- The presence of septal late gadolinium enhancement and other factors like LV dilatation, age, and arrhythmias were identified as strong predictors for serious cardiac events, such as sudden cardiac death.
SARS-CoV-2 vaccine-associated myocarditis/myocardial injury should be evaluated in the contexts of COVID-19 infection, other types of viral myocarditis, and other vaccine-associated cardiac disorders. COVID-19 vaccine-associated myocardial injury can be caused by an inflammatory immune cell infiltrate, but other etiologies such as microvascular thrombosis are also possible. The clinical diagnosis is typically based on symptoms and cardiac magnetic resonance imaging.
View Article and Find Full Text PDFArticle Synopsis
- A 37-year-old athlete underwent a 90 km bicycle test to analyze the pressure and volume in the right ventricle.
- The test showed that increased pressure in the right ventricle led to decreased efficiency in how the heart and arteries worked together, as well as a drop in cardiac output.
- To keep up oxygen delivery, the body had to increase the difference between oxygen in the arteries and veins, highlighting how right ventricle performance impacts exercise capacity.
We describe a rare case of severe low-flow, low-gradient aortic stenosis due to a calcified aortic valve chordae tendineae. The chordae was captured on cardiac computed tomography (CT) using advanced 3-dimensional image reconstruction to reveal the fibrous strand tethering the non-coronary cusp to the left ventricular outflow tract, rendering it functionally immobile. This is one of the first reported cases of severe aortic stenosis from an aortic valve chordae tendineae which highlights the utility of advanced image processing techniques in cardiac CT.
View Article and Find Full Text PDFSARS CoV-2 enters host cells via its Spike protein moiety binding to the essential cardiac enzyme angiotensin-converting enzyme (ACE) 2, followed by internalization. COVID-19 mRNA vaccines are RNA sequences that are translated into Spike protein, which follows the same ACE2-binding route as the intact virion. In model systems, isolated Spike protein can produce cell damage and altered gene expression, and myocardial injury or myocarditis can occur during COVID-19 or after mRNA vaccination.
View Article and Find Full Text PDF