Publications by authors named "R A Price"
Across multiple species, chronic vestibular stimulation activates hypothalamic regions involved in energy homeostasis and reduces body fat. This first-in-human randomised controlled trial evaluated the efficacy and safety of electrical vestibular nerve stimulation (VeNS) as a means of reducing excess body weight and fat. Overweight and obese adults were randomised 1:1 to receive 60 min of daily VeNS (n = 117) or sham stimulation (n = 124) for 6 months, together with a hypocaloric diet.
View Article and Find Full Text PDFBackground: Trafficking of immune cells to the central nervous system is hypothesized to facilitate HIV entry and immune-induced neuronal injury and is mediated by surface proteins such as chemokine receptors and α4 integrin. We longitudinally assessed immune cell activation and surface marker expression in cerebrospinal fluid (CSF) and blood and their relationship with CSF HIV RNA beginning during primary HIV infection (PHI) before and after antiretroviral therapy (ART).
Methods: Longitudinal paired blood and CSF were obtained in ART-naïve PHI (<12 month since infection) participants; some independently initiated ART during follow up.
Introduction: Newborn screening for immunodeficiency has led to the identification of numerous cases for which the causal etiology is unknown.
Methods: Here we report the diagnosis of T lymphopenia of unknown etiology in a male proband. Whole exome sequencing (WES) was employed to nominate candidate variants, which were then analyzed functionally in zebrafish and in mice bearing orthologous mutations.
Objective: To determine if the PinkWave (PW) light-curing unit (LCU) that emits red and infrared (IR) light as well as violet and blue light improves the depth of cure and degree of conversion (DC) of resin-based composites (RBCs).
Methods: The DC of RBCs at various distances was calculated from data collected at a rate of 13 Hz using attenuated total reflectance Fourier-transform infrared spectroscopy. To assess the contributions of the different wavelengths of light, optical filters were used to block the red and IR light from the PW.