Publications by authors named "R A Pennie"
Article Synopsis
- Mitochondrial gene expression is a vital and organized process that includes the replication of mitochondrial DNA (mtDNA) and the processing of mitochondrial RNA (mtRNA) within specific cellular structures.
- Recent research using super-resolution microscopy shows that immunogenic mitochondrial double-stranded RNA (mt-dsRNA) accumulates in mitochondrial RNA granules during cell proliferation, indicating a potential role in cancer cell growth.
- The presence and abundance of mt-dsRNA are influenced by mitochondrial ribonucleotide supply, suggesting a connection between mitochondrial functions and cell proliferation in cancer.
Background: The prognostic factors that determine outcome in patients with necrotizing fasciitis remain poorly understood. The aim of this study was to analyze the variables that affect the mortality and morbidity of patients with necrotizing fasciitis and to create a simple method for estimating the probability of mortality.
Methods: The authors undertook a retrospective review of all patients with necrotizing fasciitis treated in three tertiary care hospitals in Ontario, Canada, between January of 1994 and June of 2001.
Is cutaneous tuberculosis infectious? A case presentation and practical management plan.
Infect Control Hosp Epidemiol
November 2003
Infection control measures for cutaneous tuberculosis in the absence of pulmonary disease are problematic. Delays in diagnosis can lead to the exposure of many individuals. This article describes a case of cutaneous tuberculosis and the subsequent contact investigation.
View Article and Find Full Text PDFObjective: To systematically review the accuracy of modern laboratory tests for the diagnosis of serious bacterial infection in newborns.
Methods: The MEDLINE, EMBASE, and Cochrane Library databases were searched using the keywords newborn, infection, sepsis, and diagnosis. We included studies published from 1995 through 2001 that included infants younger than 90 days with proven bacterial growth in a sample from a sterile site.