Child life specialist services, practice, and utilization across health care: a scoping review.

Objective: The objective of this review was to map the available evidence regarding the scope of child life specialist services, practice, and utilization.

Introduction: The concept of child life services began in 1922 and emerged as the child life specialist services specialty in the United States in the 1970s and 1980s. Child life specialists are members of multidisciplinary health care system teams who prioritize the developmental needs of pediatric patients to support and improve patient and family health care experiences.

Microstructure and Mechanical Properties of Ti-6Al-4V Welds Produced with Different Processes.

The effect of defects and microstructure on the mechanical properties of Ti-6Al-4V welds produced by tungsten inert gas welding; plasma arc welding; electron beam welding; and laser beam welding was studied in the present work. The mechanical properties of different weld types were evaluated with respect to micro hardness; yield strength; ultimate tensile strength; ductility; and fatigue at room temperature and at elevated temperatures (200 °C and 250 °C). Metallographic investigation was carried out to characterize the microstructures of different weld types, and fractographic investigation was conducted to relate the effect of defects on fatigue performance.

COATI: Multimodal Contrastive Pretraining for Representing and Traversing Chemical Space.

Creating a successful small molecule drug is a challenging multiparameter optimization problem in an effectively infinite space of possible molecules. Generative models have emerged as powerful tools for traversing data manifolds composed of images, sounds, and text and offer an opportunity to dramatically improve the drug discovery and design process. To create generative optimization methods that are more useful than brute-force molecular generation and filtering via virtual screening, we propose that four integrated features are necessary: large, quantitative data sets of molecular structure and activity, an invertible vector representation of realistic accessible molecules, smooth and differentiable regressors that quantify uncertainty, and algorithms to simultaneously optimize properties of interest.

The difference between molecules and materials: Reassessing the role of exact conditions in density functional theory.

Exact conditions have long been used to guide the construction of density functional approximations. However, hundreds of empirical-based approximations tailored for chemistry are in use, of which many neglect these conditions in their design. We analyze well-known conditions and revive several obscure ones.

Behavioral responses to offshore windfarms during migration of a declining shorebird species revealed by GPS-telemetry.

EU member countries and the UK are currently installing numerous offshore windfarms (OWFs) in the Baltic and North Seas to achieve decarbonization of their energy systems. OWFs may have adverse effects on birds; however, estimates of collision risks and barrier effects for migratory species are notably lacking, but are essential to inform marine spatial planning. We therefore compiled an international dataset consisting of 259 migration tracks for 143 Global Positioning System-tagged Eurasian curlews (Numenius arquata arquata) from seven European countries recorded over 6 years, to assess individual response behaviors when approaching OWFs in the North and Baltic Seas at two different spatial scales (i.