Publications by authors named "R A Parslew"
Article Synopsis
- The study identifies genetic factors linked to palmoplantar pustulosis (PPP) and explores how smoking may influence the disease.
- Researchers conducted a large-scale genetic analysis and discovered that PPP is distinct from plaque psoriasis but associated with certain genetic loci, particularly linked to immune response.
- The findings suggest that smoking plays a causal role in the disease's development and highlight the involvement of specific immune pathways in PPP pathology.
Background: Palmoplantar pustulosis (PPP) is a severe inflammatory skin disorder characterized by eruptions of painful, neutrophil-filled pustules on the palms and soles. Although PPP has a profound effect on quality of life, it remains poorly understood and notoriously difficult to treat.
Objective: We sought to investigate the immune pathways that underlie the pathogenesis of PPP.
The identification of robust endotypes-disease subgroups of clinical relevance-is fundamental to stratified medicine. We hypothesized that HLA-C∗06:02 status, the major genetic determinant of psoriasis, defines a psoriasis endotype of clinical relevance. Using two United Kingdom-based cross-sectional datasets-an observational severe-psoriasis study (Biomarkers of Systemic Treatment Outcomes in Psoriasis; n = 3,767) and a large population-based bioresource (UK Biobank, including n = 5,519 individuals with psoriasis)-we compared demographic, environmental, and clinical variables of interest in HLA-C∗06:02-positive (one or two copies of the HLA-C∗06:02 allele) with those in HLA-C∗06:02‒negative (no copies) individuals of European ancestry.
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