Publications by authors named "R A Page"
As expensive therapeutics rise to the fore of heart failure management, out-of-pocket (OOP) medication costs have become increasingly relevant to patient care. Prescription medication costs influence medical decision-making and affect adherence. Yet, individualized cost estimates are seldom available during clinical encounters when prescription decisions are made.
View Article and Find Full Text PDFBackground: Proximal humerus fractures (PHF) are common with approximately 30% requiring surgical intervention. This ranges from open reduction internal fixation (ORIF) to shoulder arthroplasty (including hemiarthroplasty, total shoulder arthroplasty (TSA), reverse total shoulder arthroplasty (RTSA)). The aim of this study was to assess trends in operative interventions for PHF in an Australian population.
View Article and Find Full Text PDFBackground: This study aimed to determine the revision outcome between a centrally fixed stemless anatomic design and other total anatomic shoulder replacements using data from a large national arthroplasty registry.
Methods: The study period was from December 2011 to December 2022 and included three cohorts; primary Affinis stemless anatomic (AFS), all other primary total stemless anatomic (sTSA) and primary total stemmed anatomic shoulder arthroplasty (aTSA). The endpoint was all-cause revision using cumulative percent revision (CPR).
Objective: Osteoarthritis (OA) is a disease impacting the synovial joint complex, yet transcriptional changes specific to shoulder OA remain underexplored. This study aims to profile transcriptomic changes in periarticular tissues from patients undergoing shoulder replacement for OA. By correlating these profiles with QuickDASH scores-a validated measure of worsening shoulder function-this research seeks to understand the gene expression changes associated with clinical decline.
View Article and Find Full Text PDFArticle Synopsis
- Parkinson's disease (PD) is a neurodegenerative disorder marked by the loss of dopamine-producing neurons, with lifestyle factors like smoking and coffee consumption potentially lowering its risk.
- Studies suggest that certain components in tobacco and coffee may help protect against PD by inhibiting specific biological processes, reducing neuroinflammation, and activating protective pathways.
- The review aims to enhance our understanding of how these substances may contribute to a reduced incidence of Parkinson's disease and highlights the therapeutic potential of their compounds, although multifunctionality is not necessarily required for these effects.