Publications by authors named "R A Oldroyd"
Article Synopsis
- - The National Cancer Institute's CPTAC focuses on analyzing tumors using a proteogenomic approach, which combines genomic data with proteomic information to better understand cancer.
- - The consortium has developed a comprehensive dataset that includes genomic, transcriptomic, proteomic, and clinical data from over 1000 tumors across 10 different groups, aimed at enhancing cancer research.
- - The CPTAC team addresses challenges in integrating and analyzing multi-omics data, especially the complexities arising from combining nucleotide sequencing with mass spectrometry proteomics information.
Background: Adding docetaxel to androgen deprivation therapy (ADT) improves survival in patients with metastatic, hormone-sensitive prostate cancer, but uncertainty remains about who benefits most. We therefore aimed to obtain up-to-date estimates of the overall effects of docetaxel and to assess whether these effects varied according to prespecified characteristics of the patients or their tumours.
Methods: The STOPCAP M1 collaboration conducted a systematic review and meta-analysis of individual participant data.
The instability hypothesis proposes that family structure transitions lead to negative child outcomes through the pathway of stress. However, in many cases, family structure transitions are not associated with stress or negative child outcomes, suggesting that there are specific circumstances under which transitions are more or less stressful. Using five rounds of data (ages 1-15) from the Young Lives study ( = 8,062) which follows children and their caregivers in Ethiopia, India, Peru, and Vietnam, we had two aims: (a) to test the instability hypothesis, and (b) to examine the specific circumstances under which family structure transitions lead to stress and worsened child physical health.
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- The study investigates how various histopathologic features, such as Gleason grade and maximum cancer core length (MCCL), affect the visibility of prostate cancer on MRI scans in men with elevated PSA levels and no prior biopsy.
- It analyzes data from the Prostate MRI Imaging Study (PROMIS), focusing on MRI results correlated to specific areas of the prostate known as Barzell zones, using expert review of imaging and pathology findings.
- Findings indicate that higher Gleason scores and longer cancer core lengths significantly increase the odds of MRI visibility, while factors like prostate volume and the presence of prostatic intraepithelial neoplasia (PIN) also play important roles.
Predicting Food Safety Compliance for Informed Food Outlet Inspections: A Machine Learning Approach.
Int J Environ Res Public Health
November 2021
Consumer food environments have transformed dramatically in the last decade. Food outlet prevalence has increased, and people are eating food outside the home more than ever before. Despite these developments, national spending on food control has reduced.
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