Publications by authors named "R A O'Rourke"
Background: Mechanisms driving cerebrovascular decline during Alzheimer's disease and related dementias (ADRD) are poorly understood. Methylenetetrahydrofolate reductase (MTHFR) is an enzyme in the folate/methionine pathway. Variants in MTHFR, notably 677C>T, are associated with ADRD.
View Article and Find Full Text PDFPurpose: We examined associations between device-assessed and parent-reported physical activity with mental health indicators among children and youth with disabilities.
Method: Physical activity and mental health data were collected from a larger national surveillance study of physical activity in children and youth with disabilities in Canada. A total of 122 children and youth with disabilities (mean age = 10 y; 80% boys, 57% with developmental disability) wore a Fitbit for 28 days to measure their daily steps.
Article Synopsis
- The study investigated factors linked to low self-compassion among young adults, identifying a range of sociodemographic, psychological, and lifestyle elements.
- Data from a large sample (682 participants) were analyzed to find that 16% reported low self-compassion, with notable factors including female gender, poor sleep, overeating, and higher stress levels.
- The findings highlight the complex interplay of various influences on self-compassion, suggesting a need for further research on causality and potential interventions.
The treatment landscape for haemophilia continues to rapidly develop, and expectations for future treatment success are high. There is limited information on the challenges to accessing new and innovative therapies. The aim of this study was to explore challenges with accessing haemophilia treatment from the perspective of healthcare professionals (HCPs).
View Article and Find Full Text PDFMelanoma is the deadliest form of skin cancer with a 5-year survival rate of less than 20%. While significant strides have been made in the field of kinase-targeted and immune-based therapies for melanoma, the development of resistance to these therapeutic agents has hindered the success of treatment. Drug-resistant melanoma is particularly reliant on enhanced cap-dependent translation to drive the production of oncoproteins that promote growth and survival.
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