Recurrent herpes simplex labialis: viral replication and clinical course.

The purpose of this study was to provide additional information on the clinical course and viral replication kinetics of herpes simplex virus (HSV) in recurrent herpes labialis. Data were obtained on 20 subjects who were followed for five days from the first day of the lesion. HSV was isolated in 17 subjects (85%); 75% were positive on day 1 of the lesion.

The role of membrane association of antigens in induction of cell-mediated immunity to viruses.

Infection with viruses which bud off cell membranes (e.g. herpes, myxoviruses) is known to induce cell-mediated immunity (CMI).

Application of counterimmunoelectrophoresis in rapid detection of cytomegalovirus antibodies.

Determination of cytomegalovirus antibodies by counterimmune-electrophoresis correlated well with results of complement-fixation antibody studies. The sensitivity and specificity of the counterimmunoelectrophoresis method (vs. complement fixation) was 88.

Field trial of live attenuated influenza A/B ("Alice"/R-75) vaccine.

The reactogenicity, immunogenicity and protection effecacy of a serum inhibitor-resistant live attenuated influenza A/B ("Alice"/R-75) vaccine was determined in a group of health young volunteers. The influenza A component was derived from A/England/42/72 (H3N2) strain, and the B component from B/Hong Kong/5/72 strain. Sixty-eight subjects had hemagglutination inhibition (HAI) antibody titers to influenza A hemagglutinin (HA) antigen of less than or equal to 1:8 ("low A" group) and 75 had similarly low antibody titers to B HA antigen ("low B" group).