Publications by authors named "R A Nasyrova"
Background: To analyze the results of domestic and foreign studies of the comorbidity of anxiety-depressive disorders and discogenic back pain in adult patients.
Subjects And Methods: An analysis of Russian-language and foreign literature was carried out with a search depth of 5 years (2019-2024) in the following databases: PubMed, Springer, Wiley Online Library, Taylor & Francis Online, US National Library of Medicine National Institutes of Health, ScienceDirect and e-Library.
Results: Numerous studies have shown that depression and anxiety influence treatment outcomes in intervertebral disc degeneration (IVDD).
Article Synopsis
- Nutritional support, including iodine, plays a key role in the treatment of postpartum depressive disorder.
- Iodine is crucial for the central nervous system's development and functioning.
- The review highlights recent findings on how iodine deficiency is linked to the severity of postpartum depressive disorders in women, drawing on various studies.
The safety of the use of psychotropic drugs, widely used in neurological and psychiatric practice, is an urgent problem in personalized medicine. This narrative review demonstrated the variability in allelic frequencies of low-functioning and non-functional single nucleotide variants in genes encoding key isoenzymes of valproic acid P-oxidation in the liver across different ethnic/racial groups. The sensitivity and specificity of pharmacogenetic testing panels for predicting the rate of metabolism of valproic acid by P-oxidation can be increased by prioritizing the inclusion of the most common risk allele characteristic of a particular population (country).
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- Recent studies suggest that there may be a connection between lysosomal storage disorders (LSDs) and symptoms of schizophrenia (SCZ), indicating that lysosomal dysfunction could play a role in SCZ development.
- The research involved analyzing lysosomal enzyme activities and alpha-synuclein levels in blood samples from patients with late-onset SCZ and comparing them to patients with Parkinson's disease and healthy controls.
- Significant differences were found, including decreased enzyme activity, higher concentrations of certain lysosphingolipids, and genetic variants linked to LSDs in early-onset SCZ patients, which may contribute to understanding the overlap between these conditions.