Predictors of venous thromboembolic events in hospitalized patients with COVID-19.

COVID-19 is associated with an increased risk of venous thromboembolism (VTE) in hospitalized patients. Although prior studies have attempted to identify predictors of VTE, restricted sample size and use of administrative claims data have limited such analyses. We utilized data from hospitalized patients in the CORONA-VTE Network, a United States multicenter registry of adult patients with PCR-confirmed COVID-19 (N = 3,844).

Quantitative Protein Expression of Antibody-Drug Conjugate Targets in EGFR Mutated and Wild-Type Non-Small Cell Lung Cancer.

Background: Antibody-drug conjugates (ADCs) are a promising approach for the management of patients with non-small cell lung cancer (NSCLC). However, only a small subset of patients derive benefit from these therapies.

Patients And Methods: We employed quantitative immunofluorescence (QIF) assays to measure the levels of four ADC target proteins (HER2, TROP2, HER3, EGFR) in three NSCLC tissue microarray cohorts stratified according to EGFR mutation (EGFRmut (n=83), EGFRwt (n=128), and EGFR unknown (n=232)).

Experimental Challenge of Chinook Salmon (Oncorhynchus tshawytscha) With Tenacibaculum maritimum and Tenacibaculum dicentrarchi Fulfils Koch's Postulates.

The bacterial skin disease tenacibaculosis, caused by Tenacibaculum species, affects numerous economically important marine fish, including salmonids. This study reports the ability of three Tenacibaculum maritimum strains, belonging to different molecular O-AGC types, and a single Tenacibaculum dicentrarchi strain to induce tenacibaculosis in farmed Chinook salmon (Oncorhynchus tshawytscha, Walbaum 1792) in Aotearoa New Zealand. Naïve Chinook salmon were exposed to T.

Ultrasonic Vocalization Acoustics After Recurrent Laryngeal Nerve Injury and Recovery.

Objectives: The lack of well-defined functional acoustic correlates of vocal fold paralysis in animal models creates challenges for translating basic science studies of recurrent laryngeal nerve (RLN) injury to patients with vocal fold paralysis. Capitalizing on natural communicative rodent ultrasonic vocalizations (USVs), this study aimed to (1) investigate the impact of RLN injury on USV acoustics in both acute and chronic stages of RLN injury and (2) to identify USV parameters with the greatest ecological validity specific to RLN injury.

Methods: USVs were recorded over 2 weeks (acute) in 16 animals and over 30 weeks (chronic) in 8 animals using two USV elicitation paradigms (n = 16 non-elicited, spontaneous; n = 8 elicited, sexually paired).

Traversing Shifting Sands-the Challenges of Caring for Someone With Alzheimer's Disease and the Impact on Care Partners: Social Media Content Analysis.

Background: Social media data provide a valuable opportunity to explore the effects that Alzheimer disease (AD) has on care partners, including the aspects of providing care that have the greatest impacts on their lives and well-being and their priorities for their loved ones' treatment.

Objective: The objective of this social media review was to gain insight into the impact of caring for someone with AD, focusing particularly on impacts on psychological and emotional well-being, social functioning, daily life and ability to work, health-related quality of life, social functioning, and relationships.

Methods: We reviewed social media posts from 4 sources-YouTube (Google), Alzheimer's Association, Alzheimer Society of Canada, and Dementia UK-to gain insights into the impact of AD on care partners.