Publications by authors named "R A Morotti"
Article Synopsis
- Traditional beliefs held that placental vascular anastomoses only occur in monochorionic pregnancies, but recent reports show they can also be present in dichorionic twins.
- Conditions like twin to twin transfusion syndrome (TTTS) and twin anemia polycythemia sequence (TAPS) can affect these dichorionic pregnancies.
- The authors discuss a specific case and existing literature to highlight the need for more research on these conditions in dichorionic gestations to improve prenatal care and reduce risks.
Objectives: Progressive familial intrahepatic cholestasis (PFIC) is a group of autosomal recessive disorders caused by defects in bile secretion or transport usually presenting as cholestasis in pediatric age. Herewith, we describe 3 PFIC cases with diagnostic challenges and highlight the role of genetic analysis.
Methods: The clinical history, laboratory data, liver biopsy, and molecular analysis for each case were reviewed.
Purpose: Molecular genetic testing in conjunction with cytopathology may improve prediction of malignancy in thyroid nodules, particularly those with indeterminate cytology (Bethesda III/IV). Though now commonplace in adults, pediatric data are limited. This study examines molecular genetics of pediatric nodules with correlation to cytologic and histologic classification at time of surgery and the distribution of mutations.
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- Hepatocellular nodules can occur due to chronic liver vascular disorders, especially with conditions like portosystemic shunts (e.g., Abernethy malformation and post-Fontan procedure).
- These nodules vary widely in type, including benign forms (like regenerative nodules and focal nodular hyperplasia) as well as malignant ones (like hepatocellular carcinoma), complicating their classification based on appearance.
- A study of liver resections from patients with such vascular diseases revealed numerous nodule types, including FNH-like nodules that displayed unusual characteristics suggesting they could be neoplastic, highlighting the need for further diagnostic testing to assess cancer risk.