Publications by authors named "R A Mavrina"

Article Synopsis
  • Colchicine application to the sciatic nerve of newborn rats led to abnormal development in both fast and slow muscle types after one month.
  • Changes were observed in the contractile and histochemical properties of the extensor digitorum longus (fast muscle) and soleus (slow muscle).
  • The study highlights the crucial role of neurogenic signals from motoneurons in the differentiation of skeletal muscle fibers.
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A relative content of muscle fibers of various types and the spectrum of lactate dehydrogenase (LDH) isozymes were studied in fast-twitch (extensor digitorum longus) and slow-twitch (soleus) muscles of newborn rats, of those aged 2, 3 weeks and one month and of adult rats after neonatal sciatic denervation and application of 0.5 mM colchicine solution to the sciatic nerve. No muscle fibers of various types were found (from the level of succinate dehydrogenase activity) in one-month-old rats, whereas the control and fast-twitch muscles showed A, B and C types and the slow-twitch one B and C types.

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