Publications by authors named "R A Markosyan"
Investigation of genetic instability in patients with Diabetes Mellitus type I, II and LADA using buccal micronucleus cytome assay.
Mutat Res Genet Toxicol Environ Mutagen
December 2024
Article Synopsis
- The pilot study focused on the presence of micronuclei (MN) and other nuclear abnormalities in oral mucosa cells from patients with type I, II, and LADA diabetes, comparing results to healthy individuals.
- Cytogenetic analysis indicated that diabetes patients had significantly higher levels of MN, particularly in type I and LADA groups, suggesting potential cytotoxic and genotoxic effects of the disease.
- There was a strong correlation found between MN levels, blood glucose concentration, and glycosylated hemoglobin, highlighting the impact of diabetes on cellular health.
Background: It is unclear whether targeted monitoring of acute adrenal insufficiency (AI) related adverse events (AE) such as sick day episodes (SDEs) and hospitalization rate in congenital adrenal hyperplasia (CAH) is associated with a change in the occurrence of these events.
Aim: Study temporal trends of AI related AE in the I-CAH Registry.
Methods: In 2022, data on the occurrence of AI-related AE in children aged <18 years with 21-hydroxylase deficiency CAH were compared to data collected in 2019.
Background: Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their occurrence.
Methods: Data from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development (I-DSD) Registry. Logistic regressions, fisher's exact tests and spearman's correlation tests were performed on the data to assess associations between clinical factors and complication rates.
Importance: Testicular adrenal rest tumors (TARTs), often found in male patients with congenital adrenal hyperplasia (CAH), are benign lesions causing testicular damage and infertility. We hypothesize that chronically elevated adrenocorticotropic hormone exposure during early life may promote TART development.
Objective: This study aimed to examine the association between commencing adequate glucocorticoid treatment early after birth and TART development.
Purpose: To study the current practice for assessing comorbidity in adults with 21-hydroxylase CAH and to assess the prevalence of comorbidity in these adults.
Methods: A structured questionnaire was sent to 46 expert centres managing adults with CAH. Information collected included current therapy and surveillance practice with a particular focus on osteoporosis/osteopaenia, hyperlipidaemia, type 2 diabetes/hyperinsulinaemia, hypertension, CV disease, obesity.