Publications by authors named "R A Manning"
Article Synopsis
- Eye-tracking studies are useful for understanding language disorders like aphasia, but often suffer from small sample sizes, making results less generalizable; webcam-based tracking could address this issue.
- In a study, patients with post-stroke aphasia and matched controls performed sentence-picture matching tasks both in-lab and online to compare the sensitivity of both tracking methods.
- Results indicated that web-based tracking can effectively detect group differences in language processing in aphasia, although it showed a delay compared to in-lab tracking, suggesting further validation is needed for this promising technique.
We apply the Laplace approximation to a mathematical formulation of DNA cyclization J factors, leading to a formula that involves energies of local minima of the DNA energy, factors coming from the Hessian of the energy near each minimum, and geometric factors arising from the orientational portion of J. The approximation is derived in a quite general setting that encompasses both rigid base and rigid basepair models common in the literature. The approximation is applied to several families of 200-400 bp DNA, some relatively straight (fragments of λ-phage) and others quite bent (constructs that include up to 10 A tracts).
View Article and Find Full Text PDFBackground: This study investigated how individual differences in schizotypy differentially predicted types of loneliness - direct, social, emotional, and existential loneliness (in relationships and meaninglessness in life).
Methods: We presented participants with the brief version of the Oxford-Liverpool Inventory of Feelings and Experiences and the de Jong Giervald loneliness scale and used dominance analysis to evaluate the dominant predictors of schizotypy on loneliness. We also evaluated the impact of depression on each model.
Fab five: pioneering sociocultural influence within the culture of basketball and American society.
Front Sports Act Living
August 2024
Dating back to when the inventor of the game, James Naismith, developed a mentoring relationship with John McClendon one of the African American pioneers in basketball (founder of the "fast-break"), there are countless examples of these intersections. Entering the college basketball culture as the most decorated recruiting class in National Collegiate Athletic Association basketball history, the University of Michigan Fab Five's legacy catalyzes a new era of American basketball culture. Gracefully talented, the Fab Five abruptly disrupted the institution of basketball, the National Collegiate Athletic Association, and the identity of basketball athletes globally.
View Article and Find Full Text PDFArticle Synopsis
- * Overexpression of OTX2 in Group 3 MB cells increases growth, movement, and polarization, leading to decreased survival in animal models due to the development of brain and spinal cord metastases.
- * OTX2 activates the mTOR gene and its signaling pathway, enhancing cell migration, with a strong correlation found between OTX2 and mTOR expression in human MB samples, suggesting potential therapeutic targets by inhibiting mTORC2.