Publications by authors named "R A M Lawson"
Article Synopsis
- There is a significant sex bias in autism spectrum disorder (ASD), with 80% of cases diagnosed in males, making it challenging to uncover the biological reasons behind this difference.
- Loss of function mutations leading to dysregulated mTORC1 signaling are prevalent in individuals with tuberous sclerosis (TSC), and over 50% of those with TSC are also diagnosed with ASD, indicating a strong genetic link.
- In experiments with mice, it was found that while motor coordination deficits are similar in both male and female mice, social interaction impairments are significantly worse in males, suggesting that certain behavioral issues in ASD may vary based on sex.
Background Pulmonary function tests are central to diagnosis and monitoring of respiratory diseases but do not provide information on regional lung function heterogeneity. Fluorine 19 (F) MRI of inhaled perfluoropropane permits quantitative and spatially localized assessment of pulmonary ventilation properties without tracer gas hyperpolarization. Purpose To assess regional lung ventilation properties using F MRI of inhaled perfluoropropane in participants with asthma, participants with chronic obstructive pulmonary disease (COPD), and healthy participants, including quantitative evaluation of bronchodilator response in participants with respiratory disease.
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- Distal phalangeal and interphalangeal joint injuries are common and can create significant challenges for individuals and healthcare systems, often requiring K-wire fixation to maintain alignment.
- This study aimed to identify soft tissue and radiographic landmarks for optimal K-wire placement at the distal interphalangeal joint (DIPJ) through a retrospective analysis of 100 lateral phalangeal radiographs.
- Results indicated a 'rule of fours' for ideal entry points during K-wire insertion, suggesting that the entry should be 4 mm from the nail plate's dorsal surface and 40% volar to the soft tissue at the DIPJ crease, enhancing safety and effectiveness without fluoroscopy.
Time taken to reach treatment for eating disorders in New Zealand.
Australas Psychiatry
November 2024
Article Synopsis
- * Data from 468 survey respondents revealed that half waited over a year to seek help, with those having bulimia nervosa (BN) and binge-eating disorder (BED) taking the longest.
- * Although most were diagnosed quickly after seeking help, only about half of those referred to specialists were seen within 6 weeks, highlighting the need for improved treatment pathways and support for those seeking help.
The Immunosuppressive Drugs Scientific Committee of the International Association of Therapeutic Drug Monitoring and Clinical Toxicology established the second consensus report to guide therapeutic drug monitoring (TDM) of everolimus (EVR) and its optimal use in clinical practice 7 years after the first version was published in 2016. This version provides information focused on new developments that have arisen in the last 7 years. For the general aspects of the pharmacology and TDM of EVR that have retained their relevance, readers can refer to the 2016 document.
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