Publications by authors named "R A Lopez-Martinez"
Background: Memory responses to the antigens that an individual encounters throughout life may vary with the intensity and duration of antigen contacts or even with changes in immune status over time. This work aims to characterise specific responses to latent CMV, seasonal influenza and novel SARS-CoV-2 infections in immunocompetent individuals over 60 years of age. Specific cellular and humoral responses were identified by IFN-γ and granzyme B release by ELISpot and antibody level measurement.
View Article and Find Full Text PDFThe heightened inflammatory response observed in COVID-19 patients suggests that omega-3 fatty acids (O3FA) may confer anti-inflammatory benefits. This randomized, double-blind, single-center clinical trial aimed to evaluate the effect of O3FA supplementation in parenteral nutrition (PN) on inflammatory markers in COVID-19 patients admitted to the intensive care unit (ICU). A total of 69 patients were randomized into three groups: one received standard lipid emulsion, and two received O3FA (Omegaven) at doses of 0.
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- - The text discusses the need to identify specific subgroups of sepsis patients who might benefit from targeted treatments, known as rescue therapies, even while all patients receive standard care.
- - It highlights the classification of sepsis into various phenotypes, which are based on differing immune responses, such as hyperinflammatory or immunosuppressive states, suggesting that each may require tailored therapies for better outcomes.
- - The concept of precision medicine is emphasized, aiming to customize treatments according to the unique characteristics and mechanisms of sepsis in individual patients, focusing on developing targeted interventions.
Expansion of CD4CD28 T-lymphocytes is common in chronic heart failure (CHF) patients. Its ability to produce high levels of proinflammatory cytokines is probably the key role of these cells in CHF. IL-10 is a candidate for limiting CD4CD28 T-lymphocyte responses, whereas tumour necrosis factor (TNF) is the cytokine most closely involved in the loss of CD28 expression.
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- Streptococcal toxic shock syndrome (STTS) is a severe medical emergency characterized by rapid symptom onset and high risks of morbidity and mortality, highlighting the need for quick recognition and intervention.
- A study observed 13 patients at Vall d'Hebron University Hospital with invasive infections, primarily community-acquired pneumonia and skin infections, all receiving immediate antibiotic treatment and various organ support therapies.
- The research identified three patient phenotypes (hyperinflammatory, low perfusion, hypogammaglobulinemic) that could help tailor personalized treatments, stressing the importance of combining rapid antibiotics and strategic source control to improve survival outcomes.