Publications by authors named "R A Lazzarini"
Background: The positioning of substances, which are co-sensitizers and/or with a tendency to cross-react, is not considered in the technique when applying patch tests (PT).
Objective: To investigate the interference of the positioning of nickel (Ni), chromium (Cr) and cobalt (Co) in patch tests (PT) results, when applied close or distant from each other.
Methods: PT were performed in patients suspected of allergic contact dermatitis (ACD), using the standard battery (SB), with substances showing a tendency towards cross-react and co-sensitizers applied far apart, and an additional battery (AB) with the metals placed close to each other.
Article Synopsis
- - The study focuses on the TATA-binding protein (TBP) gene in *Taenia solium*, revealing the presence of transcription factor binding sites and two TATA-like elements in its promoter, which do not bind TBP.
- - Researchers identified key elements important for gene expression, such as the transcription start site and a downstream promoter element (DPE), and confirmed the expression of TBP-Associated Factors TsTAF6 and TsTAF9 in the parasite.
- - Molecular dynamics simulations provided insights into how TsTAF6 and TsTAF9 interact with the DPE probe, leading to a proposed interaction model that underscores their novel role in regulating transcription in *T. solium*.
Atopic dermatitis (AD) negatively affects quality of life and places a substantial financial burden on health care systems due to treatment costs and increased demand for services. To estimate the worldwide prevalence of AD, the proportion of severe cases worldwide and explore sources of heterogeneity. We searched MEDLINE, Embase, and Global Index Medicus from January 2012 up until August 30, 2022.
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