Publications by authors named "R A Koene"
Serial section transmission electron microscopy (TEM) has proven to be one of the leading methods for millimeter-scale 3D imaging of brain tissues at nanoscale resolution. It is important to further improve imaging efficiency to acquire larger and more brain volumes. We report here a threefold increase in the speed of TEM by using a beam deflecting mechanism to enable highly efficient acquisition of multiple image tiles (nine) for each motion of the mechanical stage.
View Article and Find Full Text PDFArticle Synopsis
- - Cor triatriatum is a significant cause of heart failure and atrial arrhythmias in young adults
- - Misdiagnosing this condition can lead to wrong treatments and delays in necessary surgery
- - Using integrated imaging techniques and teamwork among hospitals and cardiac specialists can improve patient outcomes
Article Synopsis
- The study investigates how cardiac electrophysiologists (EPs) perceive obstructive sleep apnea syndrome (OSAS) and its relevance in their practice, finding that 94% view it as a significant concern.
- A survey of 105 EPs revealed that while many feel inadequately trained to manage OSAS, 58% would be willing to take on this role with proper education.
- The research highlights barriers like time constraints and referral challenges that prevent EPs from being more involved in OSAS care, suggesting a need for improved training and care models in cardiology.
Hypertension is one of the most well-established risk factors for atrial fibrillation. Longstanding untreated hypertension leads to structural remodeling and electrophysiologic alterations, causing an atrial myopathy that forms a vulnerable substrate for the development and maintenance of atrial fibrillation. Hypertension-induced hemodynamic, inflammatory, hormonal, and autonomic changes all appear to be important contributing factors.
View Article and Find Full Text PDFObjective: We performed a cross-sectional analysis to determine whether nonsustained ventricular tachycardia (NSVT) and premature ventricular contractions (PVCs) were associated with dementia in a population-based study.
Methods: We included 2,517 (mean age 79 years, 26% Black) participants who wore a 2-week ambulatory continuous ECG recording device in 2016 to 2017. NSVT was defined as a wide-complex tachycardia ≥4 beats with a rate >100 bpm.