Publications by authors named "R A Kahn"

Objective: Postoperative delirium remains a common complication after cardiac surgery in high-risk patients and has been associated with prolonged intensive care unit length of stay, overall morbidity, and mortality. It has been proposed that cerebral hypoperfusion is an important etiological component. In the present study, we retrospectively queried intraoperative near-infrared spectroscopy measurements of regional cerebral oxygen saturations (rSO) during adult cardiac surgical procedures to examine the association between rSO desaturations and postoperative delirium.

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Importance: In Nigeria, 80% of breast cancer is diagnosed at an advanced stage, when clinical management is complex and necessitates multidisciplinary collaboration. The Nigerian Federal Ministry of Health promotes multidisciplinary tumor board (MDT) discussions and endorses the National Comprehensive Cancer Network Harmonized Guidelines for Sub-Saharan Africa (Harmonized Guidelines) to standardize breast cancer care, but the extent of their clinical utilization is not well understood.

Objective: To identify barriers to and facilitators of the standardization of breast cancer care in Nigeria as reflected by awareness and consultation of resource-adapted guidelines.

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Bipolar disorder is a leading contributor to the global burden of disease. Despite high heritability (60-80%), the majority of the underlying genetic determinants remain unknown. We analysed data from participants of European, East Asian, African American and Latino ancestries (n = 158,036 cases with bipolar disorder, 2.

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Article Synopsis
  • Anesthetic gases are linked to global warming, prompting a project to analyze their carbon dioxide equivalent (CDE) production and fresh gas flows (FGF) in the operating room over two years.
  • In the second year, individualized feedback through a dashboard significantly reduced median FGF from 2.0 to 1.9 l/min and total CDE from 5.10 to 3.59 kg/hr (both p < 0.001).
  • The intervention resulted in notable reductions in CDE for isoflurane and nitrous oxide, leading to faster declines in their usage rates, although it showed no significant impact on sevoflurane or nitrous oxide CDE rates.
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Following injury, skeletal muscle undergoes repair via satellite cell (SC)-mediated myogenic progression. In SCs, the circadian molecular clock gene, Bmal1, is necessary for appropriate myogenic progression and repair with evidence that muscle molecular clocks can also affect force production. Utilizing a mouse model allowing for inducible depletion of Bmal1 within SCs, we determined contractile function, SC myogenic progression and muscle damage and repair following eccentric contractile-induced injury.

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