[The participation of the serotonin link in the neurochemical mechanism of transcranial electroanalgesia].

Metergoline and 5, 7-dihydroxytryptamine were found to suppress and to prevent an electroanalgesic effect, resp. An increase in the serotonine contents in the CSF after electroanalgesia suggests an activation of the brain serotoninergic system. DL-5-hydroxytryptophan and allopurinol enhanced the electroanalgetic effect.

[The ultrastructural manifestations of serotonin-deficient states in the neurons of the dorsal raphe nucleus].

The ultrastructure of nucleus raphe dorsalis (NRD) and specific reactions of its elements were studied with a selective neurotoxin 5,7-dioxytriptamine under conditions of a primary selective injury of the serotonergic system. In this nucleus there are two groups of nervous cells reacting to the neurotoxin. The serotonergic terminal buttons are found throughout all the nucleus and are localized on part of dendrites with different diameters, on their spines and more rarely--on the bodies neurons.

[Ultrastructure of the parietal region of the brain after selective damage of the serotoninergic system].

The selective lesion of the afferent serotoninergic system by means of intracisternal administration of 5,7-dihydroxytryptamine produces certain structural rearrangements in a part of cellular elements and in various parts of the neuropil of the neocortical parietal area. The deficiency of serotoninergic innervation influences the metabolic processes. This is evident from the change in the structure of protein synthesizing apparatus in a number of postsynaptic neurons.

[Ultrastructure of the serotoninergic system of the motor area of the cerebral cortex].

Owing to the microscopical investigation, using selective neurotoxin 5,7-dihydroxytryptamine, it has been possible to reveal the serotoninergic system and targets of its innervation in the rat cerebral cortex motor area. The serotoninergic axonal varicosities and synaptic boutons are present in all layers of the neocortex. Their large amount is revealed in the I and II layers.