Publications by authors named "R A Jarillo-Luna"
Article Synopsis
- * The study found that CRS boosts TPH2 expression and activity specifically in the left adrenal gland while decreasing TPH levels in the dorsal raphe nucleus (DRN), which is involved in serotonin production.
- * Overall, the results suggest that CRS leads to higher serotonin synthesis in the adrenal glands due to increased TPH2, highlighting a complex interaction between stress and hormone regulation in the body.
Background: Borolatonin is a potential therapeutic agent for some neuronal diseases such as Alzheimer's disease (AD). Its administration exerts ameliorative effects such as those induced by the equimolar administration of melatonin in behavioral tests on male rats and in neuronal immunohistochemistry assays.
Objective: In this study, motivated by sex differences in neurobiology and the incidence of AD, the ability of borolatonin to induce changes in female rats was assessed.
Article Synopsis
- Valproic acid (VPA) is associated with liver damage, but a new compound derived from it, HO-AAVPA, shows improved antiproliferative effects against cancer.
- A study on HO-AAVPA involved testing its effects on liver toxicity in rats and mice, with results indicating it has a higher median lethal dose (LD) than 2000 mg/kg and does not cause liver injury at therapeutic doses.
- Compared to VPA, HO-AAVPA led to fewer liver lesions and less disruption to liver enzyme levels, suggesting it could be a safer alternative for cancer treatment without the risk of hepatotoxicity.
Amebiasis is an intestinal infection caused by . Amebic liver abscess (ALA) is the most common extraintestinal complication of amebiasis. In animal models of ALA, neutrophils have been shown to be the first cells to come into contact with during the initial phase of ALA.
View Article and Find Full Text PDFAmoebiasis is produced by the parasite ; this disease affects millions of people throughout the world who may suffer from amoebic colitis or amoebic liver abscess. Metronidazole is used to treat this protozoan, but it causes important adverse effects that limit its use. Studies have shown that riluzole has demonstrated activity against some parasites.
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