Publications by authors named "R A Huggins"
Replications are important for assessing the reliability of published findings. However, they are costly, and it is infeasible to replicate everything. Accurate, fast, lower-cost alternatives such as eliciting predictions could accelerate assessment for rapid policy implementation in a crisis and help guide a more efficient allocation of scarce replication resources.
View Article and Find Full Text PDFBackground: Most epidemiological studies of hidradenitis suppurativa (HS) have described homogeneous patient populations.
Objective: To characterize demographics, modifiable health behaviors, and comorbidities of HS patients within a diverse cohort.
Methods: A retrospective cross-sectional study of 13,130 HS patients within a health care system was conducted.
Article Synopsis
- A study aimed to evaluate how consistent and accurate trained raters are when using two versions of the Vitiligo Area Scoring Index (T-VASI and F-VASI) to assess the severity of vitiligo in participants.
- Results showed that inter-rater reliability improved for facial assessments, while overall reliability for full-body assessments was consistently good, indicating the method is effective.
- Limitations included a small sample size and the lack of in-person evaluations, but the findings suggest the Vitiligo Area Scoring Index is a reliable tool for assessing vitiligo severity when used by trained individuals.
Background: Breast cancers treated with aromatase inhibitors (AIs) can develop AI resistance, which is often driven by estrogen receptor-alpha (ERα/ESR1) activating mutations, as well as by ER-independent signaling pathways. The breast ER antagonist lasofoxifene, alone or combined with palbociclib, elicited antitumor activities in a xenograft model of ER + metastatic breast cancer (mBC) harboring ESR1 mutations. The current study investigated the activity of LAS in a letrozole-resistant breast tumor model that does not have ESR1 mutations.
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