Effect of a single-dose denosumab on mineral homeostasis in infertile men: insights from a pilot intervention study and a randomized controlled trial.

Background: Denosumab, a drug that inhibits RANKL to reduce bone resorption in osteoporotic postmenopausal women, has been shown to improve semen quality in a subgroup of infertile men. This study aimed to investigate the effects of denosumab on mineral homeostasis in young infertile men.

Methods: Secondary data from two clinical trials designed to test the effect on semen quality were used: (1) a pilot intervention study with 12 men receiving a single-dose of 60 mg denosumab and (2) a single-center, double-blinded, randomized clinical trial, where 100 infertile men were randomized 1:1 to receive denosumab 60 mg once sc.

Real-time spoken word recognition in deaf and hard of hearing preschoolers: Effects of phonological competition.

This study investigates how phonological competition affects real-time spoken word recognition in deaf and hard of hearing (DHH) preschoolers compared to peers with hearing in the normal range (NH). Three-to-six-year olds (27 with NH, 18 DHH, including uni- and bilateral hearing losses) were instructed to look at pictures that corresponded to words alongside a phonological competitor (e.g.

Metapopulations, the Inflationary Effect, and Consequences for Public Health.

AbstractThe metapopulation concept offers significant explanatory power in ecology and evolutionary biology. Metapopulations, a set of spatially distributed populations linked by dispersal, and their community and ecosystem level analogs, metacommunity and meta-ecosystem models, tend to be more stable regionally than locally. This fact is largely attributable to the interplay of spatiotemporal heterogeneity and dispersal (the inflationary effect).

Atypical Resting-State EEG Graph Metrics of Network Efficiency Across Development in Autism and Their Association with Social Cognition: Results from the LEAP Study.

Autism has been associated with differences in functional brain network organization. However, the exact nature of these differences across development compared to non-autistic individuals and their relationship to autism-related social cognition, remains unclear. This study first aimed to identify EEG resting-state network characteristics in autistic versus non-autistic children, adolescents, and adults.