Publications by authors named "R A Henriksen"
Article Synopsis
- - The initial step in analyzing ancient DNA involves verifying that the DNA sequencing reads are genuinely ancient, which is done by checking for typical post-mortem damage characteristics like cytosine deamination and nicks.
- - A new program called ngsBriggs uses a statistical method to quickly and accurately quantify post-mortem damage (PMD) in ancient DNA, improving the estimation of damage parameters compared to previous methods.
- - ngsBriggs not only offers greater accuracy in distinguishing ancient from modern DNA for contamination control, but it is also significantly faster than other existing techniques, making it a valuable tool for researchers.
Impact of gluten intake on clinical outcomes in patients with chronic inflammatory diseases initiating biologics: Secondary analysis of the prospective multicentre BELIEVE cohort study.
Scand J Immunol
December 2024
Article Synopsis
- Chronic inflammatory diseases (CIDs) are increasingly challenging for healthcare, with many patients responding poorly to biological treatments, leading to interest in dietary changes, particularly gluten-free diets.
- This study explored the effect of gluten intake on the clinical response to biological treatment over 14-16 weeks in 193 CID patients, comparing those with high gluten intake to those with low-to-medium intake.
- Results showed no significant differences in treatment response or secondary outcomes, indicating that gluten intake does not influence the effectiveness of biological therapy in patients with CIDs.
Recent work indicates that feralisation is not a simple reversal of domestication, and therefore raises questions about the predictability of evolution across replicated feral populations. In the present study we compare genes and traits of two independently established feral populations of chickens (Gallus gallus) that inhabit archipelagos within the Pacific and Atlantic regions to test for evolutionary parallelism and/or divergence. We find that feral populations from each region are genetically closer to one another than other domestic breeds, despite their geographical isolation and divergent colonisation histories.
View Article and Find Full Text PDFDNA methylation is a key regulator of eukaryote genomes, and is of particular relevance in the regulation of gene expression on the sex chromosomes, with a key role in dosage compensation in mammalian XY systems. In the case of birds, dosage compensation is largely absent, with it being restricted to two small Male Hyper-Methylated (MHM) regions on the Z chromosome. To investigate how variation in DNA methylation is regulated on the Z chromosome we utilised a wild x domestic advanced intercross in the chicken, with both hypothalamic methylomes and transcriptomes assayed in 124 individuals.
View Article and Find Full Text PDFIntroduction: Domestication is the process of modifying animals for human benefit through selective breeding in captivity. One of the traits that often diverges is the size of the brain and its constituent regions; almost all domesticated species have relatively smaller brains and brain regions than their wild ancestors. Although the effects of domestication on the brain have been investigated across a range of both mammal and bird species, almost nothing is known about the neuroanatomical effects of domestication on the world's most common bird: the chicken (Gallus gallus).
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