Publications by authors named "R A Hammer"
Effective interventions to prevent burnout among intensive care unit (ICU) clinicians are urgently needed. Death cafés, group discussions about death, build a sense of community and create a space for reflection on distressing events. To assess whether participation in regular death cafés can prevent burnout in ICU clinicians (physicians, nurses, pharmacists, therapists).
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- Intensive chemotherapy is the primary treatment for acute myeloid leukemia (AML), but its effectiveness is limited by heart-related side effects, known as cardiotoxicity.
- Research showed that the angiotensin II receptor type 1 (AGTR1) is connected to both AML and cardiovascular disease, and blocking AGTR1 enhances the effectiveness of chemotherapy while protecting the heart.
- The study highlighted that AGTR1-Notch1 signaling plays a crucial role in regulating genes related to cancer stemness and chemotherapy resistance in AML, suggesting a potential strategy to improve treatment outcomes for patients.
Unconventional mechanism of action and resistance to rapalogs in renal cancer.
Proc Natl Acad Sci U S A
June 2024
mTORC1 is aberrantly activated in renal cell carcinoma (RCC) and is targeted by rapalogs. As for other targeted therapies, rapalogs clinical utility is limited by the development of resistance. Resistance often results from target mutation, but mTOR mutations are rarely found in RCC.
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