[Effect of harmaline of the complex spike waveform and depression time in cerebellar Purkinje cell discharge in rat postnatal ontogenesis].

Functional relationship between waveform of complex spike (CS) and depression time of simple spike (SS) in discharge of cerebellar Purkinje cells was studied after their activation with afferent climbing fiber at different terms of postnatal ontogenesis in norm and after treatment with harmaline. The experiments were carried out on three age groups of Wistar rats: rat pups (2 weeks), the adult (4-6 months), and the old animals (22-26 months). It was established that the CS duration in norm was approximately equal in rat pups, adult, and old animals, whereas it markedly decreased from the young to the old animals during the SS depression in the Purkinje cell discharge.

[Postnatal development of the cerebellar Purkinje cell shape in guinea pig ontogenesis].

In sagittal cerebellum sections, morphometrical study of cerebellum of mature-born animals - guinea pigs - was performed using Nissl's procedure. A change of shape and volume of Purkinje cells and their nuclei in the course of the guinea pig postnatal ontogenesis was studied. It has been shown that both the growth process itself and the rate of formation of the definite form of Purkinje cells and of their nuclei in the course of ontogenesis proceeds non-uniformly.

[The number of active Purkinje cells in the microelectrod track as an indicator of maturity of the cerebellum motor function in precocial- and altricial-born animals].

In experiments on 5 age groups of anesthetized guinea pigs (from newborns to 4 weeks of postnatal ontogenesis), activity of cerebellum Purkinje cells (PC) (IV-VII lobules of cerebellar vermis) was studied in the single track of microelectrode passing through cell layers. It has been shown that as early as several hours after birth, in the superficial layer of cerebellar cortex, there are recorded occasional background-active, but functionally mature PC represented by simple and complex spikes and accordingly reflecting synaptic PC activation by afferent inputs of mossy and climbing fibers. The functional manifestation of the guinea pig motor behavior at this period of ontogenesis is act of their standing.