A Novel Method to Eliminate Preservatives in Eye Drops.

Purpose: Multiuse eye drops must maintain sterility and typically accomplish this by added preservatives. However, preservatives often cause harmful side effects. A gauze barrier dressing ("BIOGUARD") recently cleared by the FDA has an immobilized poly diallyldimethylammonium chloride (p-DADMAC) coating and is an effective antimicrobial with minimal compound release into solution.

Lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease: results of the OPUS-1 phase 3 study.

Purpose: To assess the efficacy and safety of lifitegrast ophthalmic solution 5.0% compared with placebo in subjects with dry eye disease.

Design: Prospective, randomized, double-masked, placebo-controlled, parallel arm, multicenter clinical trial.

Confocal microscopy of central toxic keratopathy.

Purpose: To examine the confocal microscopic findings in a case of late-onset central toxic keratopathy.

Methods: A 46-year-old man with central toxic keratopathy 2 months after IntraLASIK underwent confocal microscopy to examine the cellular findings within the flap interface.

Results: The confocal microscopy in central toxic keratopathy reveals activated keratocytes without aggregation of inflammatory cells.

Ocular infection secondary to gemella.

Purpose: To report four cases of ocular infection caused by Gemella species.

Methods: Microbial identification was carried out using the MicroScan Walkaway system (Dade Behring) and/or Vitek-2 (bioMérieux) and susceptibility testing with either Kirby-Bauer disc diffusion and/or Vitek-2. The paper is presented as an interventional case report.