Varying pixel resolution significantly improves deep learning-based carotid plaque histology segmentation.

Carotid plaques-the buildup of cholesterol, calcium, cellular debris, and fibrous tissues in carotid arteries-can rupture, release microemboli into the cerebral vasculature and cause strokes. The likelihood of a plaque rupturing is thought to be associated with its composition (i.e.

Trends in e-cigarette exposures reported to an Australian poisons information centre between 2017 and 2023 with a reflection on legislative changes in 2021.

Background: Australians' use of e-cigarettes has increased dramatically in the last few years, following trends worldwide. The Australian Federal government introduced legislation on October 1st, 2021, which reclassified nicotine e-cigarettes as prescription only medicine in an attempt to curb their rapid uptake, especially amongst adolescents.

Methods: This is a retrospective analysis of e-cigarette exposure cases reported to the Victorian Poisons Information Centre between January 1st, 2017, and September 30th, 2023.

Scalp and Forehead Reconstruction following Mohs Micrographic Surgery.

For proper reconstruction of scalp and forehead defects following Mohs micrographic surgery (MMS), knowledge of the unique anatomy and aesthetic importance of these structures is necessary to restore function and appearance. However, the inflexibility, convexity, and hair-bearing nature of the scalp and forehead can make reconstruction challenging. Detailed planning and precise management are essential to achieve adequate reconstructive results.

The Boston Declaration 2025: Plan and Pledges for Progress in Global Neurosurgery.

Global Neurosurgery has been described as the clinical and public health practice of neurosurgery with the primary purpose of ensuring timely, safe, and affordable neurosurgical care to all who need it. Global Neurosurgery activities in the form of mission trips, educational partnerships, and research collaborations have been in place for decades. Still, there have been no central organizing efforts to improve the harmonization of these endeavors until recently.

Histology-Specific Clinical Trial of Lenvatinib and Pembrolizumab in Patients with Sarcoma.

Purpose: Survival of patients with metastatic sarcoma remains poor, and there is a pressing need for new therapies. Most sarcoma subtypes are not responsive to immune checkpoint inhibition alone. Lenvatinib, a multireceptor tyrosine kinase inhibitor targeting tumor vasculature, has an immunomodulatory activity that contributes to its antitumor effects.