Publications by authors named "R A Deering"

Objective: To examine the effect of exercise during the first year postpartum on pelvic floor disorders and diastasis recti abdominis.

Design: Systematic review with random effects meta-analysis.

Data Sources: MEDLINE, EMBASE, CINAHL, SPORTDiscuss, Evidence-Based Medicine Reviews (Ovid), Scopus, Web of Science and ClinicalTrials.

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Background: Acute hepatic porphyria (AHP) is a group of rare but treatable conditions associated with diagnostic delays of 15 years on average. The advent of electronic health records (EHR) data and machine learning (ML) may improve the timely recognition of rare diseases like AHP. However, prediction models can be difficult to train given the limited case numbers, unstructured EHR data, and selection biases intrinsic to healthcare delivery.

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Article Synopsis
  • Odronextamab is a targeted therapy for relapsed/refractory B-cell non-Hodgkin lymphoma (R/R B-NHL) that works by engaging T-cells to attack cancer cells, showing promising results in a Phase I study with manageable safety.
  • The study involved weekly intravenous dosing and analyzed patient tumor biopsies to identify biomarkers and resistance mechanisms, finding high baseline CD20 expression in most cases but variable levels in other related antigens.
  • Results suggested that higher levels of tumor programmed cell death-ligand 1 and specific immune cell types may correlate with better responses to treatment, while mutations leading to loss of CD20 expression may contribute to resistance.
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Returning to running postpartum presents challenges such as musculoskeletal pain and pelvic floor dysfunction for some females, but there is little guidance on developing and progressing postpartum training programmes. This study aims to establish expert consensus recommendations on designing and modifying a postpartum return-to-running training programme, highlight costs and access to qualified professionals as potential barriers and discuss clinical, research and sports policy implications.A three-round Delphi survey of clinical and exercise professionals working with postpartum runners was conducted.

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Female athletes have identified a lack of guidance as a barrier to successfully returning to running postpartum, and existing guidelines are vague. Our aim was to define the current practice of determining postpartum run-readiness through a consensus survey of international clinicians and exercise professionals in postpartum exercise to assist clinicians and inform sport policy changes.A three-round Delphi approach was used to gain international consensus from clinicians and exercise professionals on run-readiness postpartum.

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