Publications by authors named "R A De Moor"
Recent interest has been in using mIDH inhibitors in patients with IDH-mutant gliomas. This review paper summarizes the indications, side effects, recommended dosing, and management for patients on ivosidenib and vorasidenib.
View Article and Find Full Text PDFIntroduction: Indirect treatment comparisons (ITCs) evaluate novel treatments compared to appropriate comparators when direct evidence is unavailable or infeasible. The objective of this study was to highlight the prevalence of different ITC methods in oncology drug submissions and to provide insights into how ITCs have been used in recent regulatory approval, reimbursement recommendations, or pricing decisions across various regions and diverse assessment frameworks.
Methods: A targeted literature review was conducted to identify assessment documents for oncology drug submissions that included ITCs.
A rare case of pediatric distal middle cerebral artery aneurysm.
SAGE Open Med Case Rep
September 2024
Article Synopsis
- Pediatric middle cerebral artery aneurysms can lead to serious complications like rupture and subarachnoid hemorrhage.
- It's uncommon to find unruptured middle cerebral artery aneurysms in infants.
- This case discusses a 13-month-old boy who received clip ligation to treat an incidental M3 aneurysm.
Article Synopsis
- The study aims to enhance the quality and transparency of indirect treatment comparisons (ITCs) in healthcare by identifying key techniques and assessing their suitability as evidence for healthcare interventions.
- Researchers reviewed 68 guidelines from various global authorities, highlighting a preference for certain ITC methods that account for population differences rather than naive comparisons, with updates reflecting recent clinical needs.
- The findings indicate that while ITCs are valuable for understanding clinical effectiveness when direct trials aren't feasible, the appropriateness of the ITC method depends on data quality and the context of healthcare decisions.