Publications by authors named "R A Cannon"
Data-driven models of neurons and circuits are important for understanding how the properties of membrane conductances, synapses, dendrites, and the anatomical connectivity between neurons generate the complex dynamical behaviors of brain circuits in health and disease. However, the inherent complexity of these biological processes makes the construction and reuse of biologically detailed models challenging. A wide range of tools have been developed to aid their construction and simulation, but differences in design and internal representation act as technical barriers to those who wish to use data-driven models in their research workflows.
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- RSA is linked to metabolic imbalances at the maternal-fetal interface, especially concerning essential fatty acids and oxylipins, which may contribute to the risk of spontaneous abortion.
- Research involved analyzing samples from women experiencing spontaneous abortion and those with normal pregnancies, measuring fatty acid levels and enzyme expressions using advanced techniques like GC-MS and LC-MS.
- Findings showed that women with recurrent spontaneous abortion had higher omega-6 fatty acid levels in their plasma and chorionic villi but lower levels in the decidua, suggesting a possible dysregulation of fatty acid transport affecting pregnancy outcomes.
Article Synopsis
- Women with inflammatory bowel disease (IBD) face challenges in reproductive health, with many not receiving adequate contraception counseling despite a high comfort level in discussing these issues with their healthcare providers.
- A study of 338 women revealed that while 74% used contraception, long-acting methods were relatively underutilized, especially among those in remission, indicating a need for improved education on contraceptive options.
- Key preferences for contraceptive methods included effectiveness, ease of use, and minimal side effects, emphasizing the importance of better communication and support from healthcare professionals in managing reproductive health for women with IBD.
Background: Diphtheria is a recurrent threat with endemic still occurs in many parts of the world. The standard of care is horse serum-derived diphtheria antitoxin (eDAT), which is in critical short supply globally. S315 is a fully human, monoclonal immunoglobulin G1 neutralizing antibody, specific to the receptor-binding domain of diphtheria toxin.
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